KEYNOTE SPEAKERS

Prof. Brian Yuliarto, S.T., M.Eng., Ph.D

Modification of Metal Organic Frameworks (MOFs) for Electrochemical and Optical Biosensor

Brian YULIARTO, a) Ni Luh Wulan SEPTIANI, a,b) Gilang GUMILAR,c), Kariana Kusuma DEWI,a) Lena HAMIDAR,a)

a) Advanced Functional Materials Research Group, Faculty of Industrial Technology, Institut Teknologi Bandung, Bandung 40132, Indonesia; b) Research Center fo Advanced Materials, National Research and Innovation Agency, South Tangerang 15314, Indonesia; c National Research and Innovation Agency, Central Jakarta, Indonesia.

presenting author brian@itb.ac.id

Abstract

Metal organic frameworks (MOFs) are one class of porous materials that gained significant interest in sensing applications because of their unique properties including high surface area, abundance active sites, tunable pore, and tunable surface chemistry. In addition, sensing properties can be significantly improved by controlling morphology of MOFs which basically induce defect on their surface. The function of the defect is to open active sites, enabling surface modification, and increase catalytic activity. For example, one dimensional HKUST-1 was prepared using a simple co-precipitation method with the presence of thiethanolamine as a pH modulator and structure directing agent at the same time. Using electrochemical techniques, 1D HKUST-1 modified glassy carbon electrode displays limit of detection of 12 pg/mL in detecting NS1 Dengue virus antigen. The amorphous HKUST-1 was also successfully prepared using the similar technique. The limit of detection can be lowered to 1.64 pg/mL [1]. In addition, modification of HKUST-1 was also achieved by incorporating different metal forming bimetal HKUST-1. For example, cobalt was incorporated into HKUST-1 to improve the sensing performance toward Dengue virus. With the copper to cobalt ratio of 2:1, the limit of detection 0.17 pg/mL. Aside from Dengue virus, amorphous HKUST-1 was applied as Hepatitis B sensor. In this case anti-HbsAg was used as a bioreceptor [2,3]. The immunosensor has detection limit down to 0.87 pg/mL and has high potential for early detection of Hepatitis B. Another kind of MOF was also utilized in optical biosensor such as UiO-66. The UiO-66 modified gold chip can detect the presence of HER2 which is biomarker for breast cancer anti RBD which is protein in Sars-cov-2, with detection limit of 5.92 ng/mL and 0.18 ng/mL respectively. These results show the high potential of MOFs in biosensor application.

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