Currently, the are many studies that focus on sensor platforms that can be used in chemical sensor and biosensor development, such as lab-on-a-chip, lab-on-a-tube, lab-on-a-paper, etc. In this regard, the use of a disposable pipette tip was studied to create a lab-on-a-tip (LOT) approach. The configuration of a pipette tip, optical or electrochemical detection, and chemical sensor or biosensor shows the compatibility of creating a versatile one-shot sensor system for target analyte detection in various samples, ranging from environmental, and food to clinical samples. In these works, the sensing principle, configurations, and some examples have been applied for heavy metals and pesticide detections. Under optimal experimental parameters, the LOT could detect a low level of a target analyte. In many examples, the LOT results in the detection of a target analyte, show a good agreement with the standard method, such as spectroscopy or chromatography method.

Key Words: LOT; chemical sensors, biosensors; electrochemical; optical detection.