Chitosan obtained from shelled animal waste such as shrimp, clams, crabs, crabs and others. Chitosan was chosen because of its properties such as biocompatible, biodegradable, and nontoxic. Chitosan has several biochemical activities such as anti-infection, stimulation of angiogenesis, and activation of growth factors. Chitosan also has ability to increase the permeation of substances across biological membranes, so it has the potential to be used as a matrix in drug delivery systems. Currently, Chitosan has been widely used in various fields such as agriculture, water treatment, food, cosmetics, biomedical and pharmaceutical.

We have published a paper about synthesis nano chitosan by ionic gelation method. Ionic gelation is a based on the ability of polyelectrolyte ions to cross bonds and form hydrogel beads which known as gel balls. The use of nano chitosan as a coating material gave better results than micrometer sized chitosan. Nano chitosan can control the release and maintain the stability of the active ingredient, as well as increase the activity of the active ingredient in pharmaceutical and cosmetic preparations. We have succeeded produce nano chitosan in particle size lower than 100nm.